Stable Cell Lines for Reliable rAAV Manufacturing

From Bench to Bioreactor — One Cell. One Standard.

Key features

What stable producer cell lines unlock for rAAV manufacturing.
One-Time Cell Line Creation
All plasmid DNA is integrated into the host cell genome, eliminating the need for repeated plasmid manufacturing costs for every batch.
Built-In Consistency
Stable genomic integration of AAV components creates a fixed, heritable production platform — eliminating transient transfection variability and enabling the high reproducibility that GMP compliance and commercial-scale manufacturing demands.
Scalable Manufacturing
Stable producer cell lines enable seamless scale-up and tech transfer, accelerating efficient and reliable clinical and commercial manufacturing.
Reduced Manufacturing Burden
Reduced raw materials, streamlined process steps, and lower batch variability simplify manufacturing and significantly reduce the cost of goods sold (COGS).
process

Transition from Transient to Stable rAAV Production

A Fully Characterized Cell Line Pedigree Enabling Seamless Development from Early Research to Commercial Manufacturing.
End-to-end support for R&D and CMC readiness
Genome stability & praticity control
Transcriptomics & epigenomics
Clonality
Transgene integrity
Integration sites
Safety
QA / QC
Timeline

From Transfection to Transfer-Ready RCB in just 16 Weeks!

economics

Stable Manufacturing Fundamentally Changes rAAV Economics

Cut batch timelines from ~10 months to ~1 month while reducing cost per dose by 17×
72%
Lower Batch Cost
$2.74M → $767K per 200 L batch
1
Eliminate Plasmid DNA
  • TTT: 3 plasmids at $1.5-2M/plasmid
  • 8-month lead time
-->  Removed entirely
17×
Cheaper Per Dose
$54,800 → $3,196 per 1013 vg
2
Reduce Batch Failures
  • TTT: 20-30% batch failure
  • Stable: <5%
-->  Predictable supply
More Doses Per Batch
Full-capsid ratio increased from 20-30% to 65-75%
3
Increase Yield
  • 3× more full-capsid ratio with Xcell™
  • More doses per batch
-->  Cost per patient dramatically reduced

Stable manufacturing wins every time.

Bottom Line: Stable is not an incremental improvement – it is the seismic shift required for rAAV to address indications beyond ultra-rare disease.